Electrostatic inhibition of hemolysis induced by organotin compounds
نویسندگان
چکیده
منابع مشابه
Organotin Compounds and the Environment
Organotin compound that have at least one Sn-C bond have wide commercial applications as PVC stabilizer, antifouling agent in paint and as agrochemicals. The general formula for organotin compounds is R4SnX4 - n where R is normally alkyl or aryl groups and X=Cl-, OH-, CH3COO- . If n=3, the compound has the highest toxicity, for example Et3SnOAC has LD 50 4mg/Kg ( rats ) and this is the m...
متن کاملSpeciation analysis of organotin compounds by HPLC-ICP-MS
The toxicity of trace metals in our food, in the products we use and in the environment is an area of increasing concern. As our knowledge has grown, we have come to understand that the toxicity of these elements is highly dependent on the molecular species to which they are chemically bound. Increasingly, regulations are being written to reflect this reality. Monitoring elemental species requi...
متن کاملDevelopmental toxicity of organotin compounds in animals
*Correspondence: Xiao Huang, Institute of Cellular and Developmental Biology, College of Life Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, China e-mail: [email protected]; Huahong Shi, State Key Laboratory of Estuarine and Coastal Research, East China Normal University, 3663 Zhongshan Road (N), Shanghai 200062, China e-mail: [email protected] Organotin compo...
متن کاملStructural basis for PPARγ transactivation by endocrine-disrupting organotin compounds
Organotin compounds such as triphenyltin (TPT) and tributyltin (TBT) act as endocrine disruptors through the peroxisome proliferator-activated receptor γ (PPARγ) signaling pathway. We recently found that TPT is a particularly strong agonist of PPARγ. To elucidate the mechanism underlying organotin-dependent PPARγ activation, we here analyzed the interactions of PPARγ ligand-binding domain (LBD)...
متن کاملOrganotin compounds: industrial applications and biological investigation.
According to Ross (1), there are three main areas in which organotin compounds have product and process utility: (1) heat stabilizers; (2) catalytic agents; (3) biocidal compounds. Organotin derivatives account for the fourth largest production of organometallics amounting to about 3-4 million pounds per year as compared with about 485 million pounds per year for organolead compounds. Originall...
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ژورنال
عنوان ژورنال: IUBMB Life
سال: 1998
ISSN: 1521-6543
DOI: 10.1080/15216549800201322